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Projects

In the second funding period, the SFB 684 is comprised of 16 research projects.

Nuclear architecture in normal and malignant hematopoietic cell types studied by quantitative, correlative microscopy  [more]
Repair and signalling of DNA double-strand breaks in normal and malignant hematopoiesis is the main agenda.  [more]
The role and regulation of DNA methylation in normal and malignant hematopoiesis  [more]
A transgenic mouse model for CALM/AF10 leukemias  [more]
Nucleolar targets of chemotherapy involved in cell cycle and growth control  [more]
Validation of crucial signaling pathways in oncogene driven leukemias by an siRNA based in vivo approach  [more]
Mechanisms of leukemic transformation by the receptor tyrosine kinase FLT3 in vitro and in vivo  [more]
The role of Notch-signaling in B cell development, activation and lymphomagenesis  [more]
Molecular control of hematopoietic stem cell self renewal and differentiation  [more]
MALT1 signaling in Lymphomagenesis  [more]
Epigenetic regulation of hematopoiesis  [more]
The ubiquitin-editing enzyme A20 in B cell physiology and malignancy  [more]
Functional analysis of histone variants during normal and malignant hematopoiesis  [more]
The role of the germinal center kinase family member TNIK in hematopoiesis and signaling  [more]
Functional Characterization of AML-associated Mutants of Nucleophosmin  [more]
The effect of TRAIL on primary leukemia cells and leukemic stem cells  [more]
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