It is the aim of this collaborative research center (CRC) to dissect the molecular pathways and mechanisms that govern normal and malignant hematopoiesis. This will be accomplished by a close interaction between investigations focusing on single molecules or defined molecular pathways and analyses addressing the complexity of the disease and the physiological differentiation processes by using sophisticated model systems and patient material. The basis for this challenging approach is provided through the cooperation between well established basic researchers, junior group leaders and physician scientists and is supported by the access to patient material from the controlled clinical trials of the German AML Cooperative Group. [more]